Cdc42^tm1.1Ayam
Targeted Allele Detail

Summary

• Symbol: Cdc42^tm1.1Ayam
• Name: cell division cycle 42; targeted mutation 1.1, Atsushi Yamada
• MGI ID: MGI:5320442
• Synonyms: Cdc42^fl
• Gene: Cdc42 Location: Chr4:137047007-137085031 bp, - strand Genetic Position: Chr4, 69.83 cM
• Alliance: Cdc42^tm1.1Ayam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:184022
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:184022)

Disease models

Expression

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	28 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc42 Mutation: 43 strains or lines available

References

• Original: J:184022 Aizawa R, et al., Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development. Mech Dev. 2012 Mar;129(1-4):38-50
• All: 10 reference(s)