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Tg(NPHS2-Trpc6*E896K)F75aWalz
Transgene Detail
Nomenclature
Symbol: Tg(NPHS2-Trpc6*E896K)F75aWalz
Name: transgene insertion F75a, Katherina Walz
MGI ID: MGI:5319640
Synonyms: Trpc6-HA E896K
Transgene: Tg(NPHS2-Trpc6*E896K)F75aWalz  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J x CBA/J
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(NPHS2-Trpc6*E896K)F75aWalz expresses 1 gene
 
Mutation detailsThe Trpc6-HA wildtype cDNA sequence was made by modifying a Trpc6 cDNA sequence (encoding a 930 amino acid protein) originally isolated from mouse brain tissue by both repairing an A2615G point mutation (D872G) and also by in-frame addition of an influenza virus hemaglutinin epitope (HA-tag) at the 3' end. The cDNA sequence was placed downstream of a 2.5 kbp fragment from the promoter/enhancer region of the human podocin locus (NPHS2) and upstream from a bovine growth hormone polyA sequence. The G2686A nucleotide substitution was introduced to produce the amino acid substitution of lysine for glutamic acid at position 896 (E896K). Lines F73a and F75a were generated. (J:165112)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:165112 Krall P, et al., Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease. PLoS One. 2010;5(9):e12859
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory