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Transgene Detail
Symbol: Tg(NPHS2-Trpc6*P111Q)F615Walz
Name: transgene insertion F615, Katherina Walz
MGI ID: MGI:5319638
Synonyms: Trpc6-HA P111Q
Transgene: Tg(NPHS2-Trpc6*P111Q)F615Walz  Location: unknown  
Strain of Origin:  C57BL/6J x CBA/J
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(NPHS2-Trpc6*P111Q)F615Walz expresses 1 gene
Mutation detailsThe Trpc6-HA wildtype cDNA sequence was made by modifying a Trpc6 cDNA sequence (encoding a 930 amino acid protein) originally isolated from mouse brain tissue by both repairing an A2615G point mutation (D872G) and also by in-frame addition of an influenza virus hemaglutinin epitope (HA-tag) at the 3' end. The cDNA sequence was placed downstream of a 2.5 kbp fragment from the promoter/enhancer region of the human podocin locus (NPHS2) and upstream from a bovine growth hormone polyA sequence. The C332A nucleotide substitution was introduced to produce the amino acid substitution of glutamine for proline at position 111 (P111Q). Lines F615 and F615 were generated. (J:165112)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:165112 Krall P, et al., Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease. PLoS One. 2010;5(9):e12859
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.04
The Jackson Laboratory