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Targeted Allele Detail
Symbol: Pmchtm1.1(DTR)Rpa
Name: pro-melanin-concentrating hormone; targeted mutation 1.1, Richard D Palmiter
MGI ID: MGI:5319632
Synonyms: PmchDTR
Gene: Pmch  Location: Chr10:88091072-88092374 bp, + strand  Genetic Position: Chr10, 43.7 cM, cytoband C2
Germline Transmission:  Earliest citation of germline transmission: J:181947
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe human diphtheria toxin receptor followed by an IRES-EGFP reporter gene and an FRT flanked neo cassette replaced parts of the first and second coding exons via homologous recombination. Flp mediated recombination removed the neo cassette. (J:181947)
Schematic of the Pmchtm1.1(DTR)Rpa allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pmch Mutation:  6 strains or lines available
Original:  J:181947 Wu Q, et al., Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3155-60
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory