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Pmchtm1.1(DTR)Rpa
Targeted Allele Detail
Nomenclature
Symbol: Pmchtm1.1(DTR)Rpa
Name: pro-melanin-concentrating hormone; targeted mutation 1.1, Richard D Palmiter
MGI ID: MGI:5319632
Synonyms: PmchDTR
Gene: Pmch  Location: Chr10:88091072-88092374 bp, + strand  Genetic Position: Chr10, 43.7 cM, cytoband C2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:181947
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe human diphtheria toxin receptor followed by an IRES-EGFP reporter gene and an FRT flanked neo cassette replaced parts of the first and second coding exons via homologous recombination. Flp mediated recombination removed the neo cassette. (J:181947)
Schematic of the Pmchtm1.1(DTR)Rpa allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pmch Mutation:  6 strains or lines available
References
Original:  J:181947 Wu Q, et al., Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3155-60
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory