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Transgene Detail
Symbol: Tg(NPHS2-Trpc6)F419Walz
Name: transgene insertion F419, Katherina Walz
MGI ID: MGI:5319631
Synonyms: Trpc6-HA wt
Transgene: Tg(NPHS2-Trpc6)F419Walz  Location: unknown  
Strain of Origin:  C57BL/6J x CBA/J
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(NPHS2-Trpc6)F419Walz expresses 1 gene
Mutation detailsThe Trpc6-HA wildtype cDNA sequence was made by modifying a Trpc6 cDNA sequence (encoding a 930 amino acid protein) originally isolated from mouse brain tissue by both repairing an A2615G point mutation (D872G) and also by in-frame addition of an influenza virus hemaglutinin epitope (HA-tag) at the 3' end. The cDNA sequence was placed downstream of a 2.5 kbp fragment from the promoter/enhancer region of the human podocin locus (NPHS2) and upstream from a bovine growth hormone polyA sequence. Line F419 contains 2-4 copies of the transgene. (J:165112)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:165112 Krall P, et al., Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease. PLoS One. 2010;5(9):e12859
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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