Desi2^tm1Mche
Targeted Allele Detail

Summary

• Symbol: Desi2^tm1Mche
• Name: desumoylating isopeptidase 2; targeted mutation 1, Mina Chen
• MGI ID: MGI:5319234
• Gene: Desi2 Location: Chr1:178014983-178080164 bp, + strand Genetic Position: Chr1, 82.93 cM, cytoband H3
• Alliance: Desi2^tm1Mche page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183741
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3. A neo cassette with a 3' loxP site was inserted downstream of exon 3. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts and the brain. (J:183741)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Desi2 Mutation: 25 strains or lines available

References

• Original: J:183741 Cai P, et al., PNAS4 knockout does not induce obviously neurocytes apoptosis and abnormal development in mice brain. Mol Biol Rep. 2012 Jan;39(1):621-8
• All: 1 reference(s)