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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Tomomichi Watanabe
MGI ID: MGI:5318566
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:182731
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata expresses 1 gene
Mutation detailsThe expression cassette was knocked into the locus. This vector contains a splice acceptor, ATG start codon, neo cassette, polyadenylation sequence, 5' Thy1 promoter region, human open reading frame, and 3' Thy1 promoter region. (J:182731)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  310 strains or lines available
Original:  J:182731 Watanabe T, et al., FBL2 regulates amyloid precursor protein (APP) metabolism by promoting ubiquitination-dependent APP degradation and inhibition of APP endocytosis. J Neurosci. 2012 Mar 7;32(10):3352-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory