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Targeted Allele Detail
Symbol: Slc12a6tm1Garo
Name: solute carrier family 12, member 6; targeted mutation 1, Guy A Rouleau
MGI ID: MGI:5318538
Synonyms: Slc12a6flox
Gene: Slc12a6  Location: Chr2:112265825-112363163 bp, + strand  Genetic Position: Chr2, 56.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:183239
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT and LoxP flanked neo cassette was inserted upstream of exon 18 and a loxP site was inserted downstream of exon 18 via homologous recombination. (J:183239)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc12a6 Mutation:  96 strains or lines available
Original:  J:183239 Shekarabi M, et al., Loss of neuronal potassium/chloride cotransporter 3 (KCC3) is responsible for the degenerative phenotype in a conditional mouse model of hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum. J Neurosci. 2012 Mar 14;32(11):3865-76
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory