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Targeted Allele Detail
Symbol: Stab2tm1Ami
Name: stabilin 2; targeted mutation 1, Atsushi Miyajima
MGI ID: MGI:5318244
Gene: Stab2  Location: Chr10:86677062-86843889 bp, - strand  Genetic Position: Chr10, 43.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:182239
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsGenomic sequence including most of exon 1 and part of intron 1 was replaced with a lacZ and neo expressing cassette via homologous recombination. RT-PCR and immunostaining confirmed the absence of expression in homozygous mice. (J:182239)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stab2 Mutation:  86 strains or lines available
Original:  J:182239 Hirose Y, et al., Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4263-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.21
The Jackson Laboratory