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Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, David C Chan
MGI ID: MGI:5318241
Synonyms: Gt(ROSA)26Sortm1.1(CAG-Mito-Dendra2)Dcc, mito-Dendra2, PhAMexcised
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:183305
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, Reporter)
Mutation:    Insertion
 
Mutation detailsDendra2 (a green to red irreversibly photoswitchable monomeric fluorescent protein derived from octocoral Dendronephthya sp.) fused to the mitochondrial targeting signal of subunit VIII of cytochrome c oxidase (mito-Dendra2), bovine growth hormone (bGH) polyadenylation signal, and an FRT-flanked neomycin cassette were introduced to Gt(ROSA)26Sor downstream of a CAG (CMV-beta-actin) promoter and loxP-flanked termination signal. Flp-mediated recombination removed the neo cassette. (J:183306, J:189358)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  258 strains or lines available
References
Original:  J:183306 Chan DC, Direct Data Submission 2012/05/14. MGI Direct Data Submission. 2012;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory