Acot11^tm1Deco
Targeted Allele Detail

Summary

• Symbol: Acot11^tm1Deco
• Name: acyl-CoA thioesterase 11; targeted mutation 1, David E Cohen
• MGI ID: MGI:5317949
• Gene: Acot11 Location: Chr4:106601752-106662195 bp, - strand Genetic Position: Chr4, 49.75 cM, cytoband C7
• Alliance: Acot11^tm1Deco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182660
• Parent Cell Line: PTL1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 12 were replaced with a floxed neo cassette via homologous recombination. Quantitative RT-PCR and immunoblot analysis confirmed the absence of expression in brown adipose tissue from homozygous mice. (J:182660)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acot11 Mutation: 45 strains or lines available

References

• Original: J:182660 Zhang Y, et al., Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance. Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5417-22
• All: 3 reference(s)