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Akt1tm2Mbb
Targeted Allele Detail
Nomenclature
Symbol: Akt1tm2Mbb
Name: thymoma viral proto-oncogene 1; targeted mutation 2, Morris J Birnbaum
MGI ID: MGI:5317852
Synonyms: Akt1loxP
Gene: Akt1  Location: Chr12:112653821-112674796 bp, - strand  Genetic Position: Chr12, 61.2 cM, cytoband F1-F2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182721
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a single loxP site upstream of exon 3, and a loxP-flanked neomycin resistance (neo) cassette downstream of exon 4 of the gene. (J:182721)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt1 Mutation:  24 strains or lines available
References
Original:  J:182721 Wan M, et al., Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity. Mol Cell Biol. 2012 Jan;32(1):96-106
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory