Pld2^tm1.1Mjow
Targeted Allele Detail

Summary

• Symbol: Pld2^tm1.1Mjow
• Name: phospholipase D2; targeted mutation 1.1, Michael JO Wakelam
• MGI ID: MGI:5317803
• Gene: Pld2 Location: Chr11:70430890-70448936 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Pld2^tm1.1Mjow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183062
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 13. A floxed neo cassette was inserted downstream of exon 15. Cre-mediated recombination removed exons 13 through 15 and the neo cassette. Western blot analysis confirmed the absence of protein expression. (J:183062)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pld2 Mutation: 48 strains or lines available

References

• Original: J:183062 Norton LJ, et al., PLD1 rather than PLD2 regulates phorbol-ester-, adhesion-dependent and Fc{gamma}-receptor-stimulated ROS production in neutrophils. J Cell Sci. 2011 Jun 15;124(Pt 12):1973-83
• All: 2 reference(s)