S100a4^tm1.1Abres
Targeted Allele Detail

Summary

• Symbol: S100a4^tm1.1Abres
• Name: S100 calcium binding protein A4; targeted mutation 1.1, Anne R Bresnick
• MGI ID: MGI:5317430
• Gene: S100a4 Location: Chr3:90511077-90513349 bp, + strand Genetic Position: Chr3, 39.27 cM, cytoband F1-F2
• Alliance: S100a4^tm1.1Abres page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182865
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette and exons 2 and 3. Western blot analysis confirmed the absence of protein expression in the bone marrow and mouse embryonic fibroblasts. (J:182865)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any S100a4 Mutation: 24 strains or lines available

References

• Original: J:182865 Li ZH, et al., S100A4 regulates macrophage chemotaxis. Mol Biol Cell. 2010 Aug 1;21(15):2598-610
• All: 6 reference(s)