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Gjc1tm1.2(Gjd2)Kwi
Targeted Allele Detail
Summary
Symbol: Gjc1tm1.2(Gjd2)Kwi
Name: gap junction protein, gamma 1; targeted mutation 1.2, Klaus Willecke
MGI ID: MGI:5317163
Synonyms: Cx45Cx36
Gene: Gjc1  Location: Chr11:102690405-102710526 bp, - strand  Genetic Position: Chr11, 66.48 cM
Alliance: Gjc1tm1.2(Gjd2)Kwi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182927
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Mutation detailsCre-mediated recombination of Gjc1tm1.1(Gjd2)Kwi removed exon 3 and allowed for expression of the mouse Gjd2 cDNA. Western blot analysis confirmed the expression of Gjd2 in the retina. (J:182927)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gjc1 Mutation:  33 strains or lines available
References
Original:  J:182927 Frank M, et al., Neuronal connexin-36 can functionally replace connexin-45 in mouse retina but not in the developing heart. J Cell Sci. 2010 Oct 15;123(Pt 20):3605-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory