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Targeted Allele Detail
Symbol: Gjc1tm1.1(Gjd2)Kwi
Name: gap junction protein, gamma 1; targeted mutation 1.1, Klaus Willecke
MGI ID: MGI:5317162
Synonyms: Cx45fl(Cx36)
Gene: Gjc1  Location: Chr11:102799579-102819700 bp, - strand  Genetic Position: Chr11, 66.48 cM
Germline Transmission:  Earliest citation of germline transmission: J:182927
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 3. A construct containing an FRT-flanked neo cassette, loxP site, mouse cDNA, IRES, and nuclear localized lacZ was placed downstream of exon 3. Flp-mediated recombination removed the neo cassette. (J:182927)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gjc1 Mutation:  17 strains or lines available
Original:  J:182927 Frank M, et al., Neuronal connexin-36 can functionally replace connexin-45 in mouse retina but not in the developing heart. J Cell Sci. 2010 Oct 15;123(Pt 20):3605-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory