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Del(5Limk1-Trim50)2Uta
Targeted Allele Detail
Nomenclature
Symbol: Del(5Limk1-Trim50)2Uta
Name: deletion, Chr 5, Uta Francke 2
MGI ID: MGI:5317121
Synonyms: DD, Del2Uta
Gene: Del(5Limk1-Trim50)2Uta  Location: Chr5:134684893-135396859 bp  Genetic Position: Chr5, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182796
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Intergenic deletion, Intragenic deletion
  Del(5Limk1-Trim50)2Uta involves 28 genes/genome features (Gm25315, Limk1, Gm10369 ...) View all
 
Mutation detailsCre-mediated recombination of ES cells carrying Limk1tm1Uta and Trim50tm1Uta removed all genomic sequence between the two alleles (including Limk1, Eln, Wbscr26, Cldn13, Wbscr27, Cldn4, Cldn3, Abhd11, Stx1a, Wbscr22, Wbscr18, Vps37d, Mlxipl, Tbl2, Bcl7b, Baz1b, Fzd9, Fkbp6 and Trim50). (J:182796)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(5Limk1-Trim50)2Uta Mutation:  1 strain or line available
References
Original:  J:182796 Li HH, et al., Induced chromosome deletions cause hypersociability and other features of Williams-Beuren syndrome in mice. EMBO Mol Med. 2009 Apr;1(1):50-65
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory