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Astltm1Lex
Targeted Allele Detail
Summary
Symbol: Astltm1Lex
Name: astacin like metalloendopeptidase; targeted mutation 1, Lexicon Genetics
MGI ID: MGI:5316737
Synonyms: Sas1b-
Gene: Astl  Location: Chr2:127180559-127199571 bp, + strand  Genetic Position: Chr2, 61.93 cM, cytoband F
Alliance: Astltm1Lex page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182712
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES, lacZ and neo cassette replaced exons 5 through 7. Immuno-fluorescence localization confirmed the absence of protein expression in the microvillar domain of mature M2 eggs. (J:182712)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Astl Mutation:  23 strains or lines available
References
Original:  J:182712 Sachdev M, et al., Oocyte specific oolemmal SAS1B involved in sperm binding through intra-acrosomal SLLP1 during fertilization. Dev Biol. 2012 Mar 1;363(1):40-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory