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Kiss1rtm1.1Lex
Targeted Allele Detail
Nomenclature
Symbol: Kiss1rtm1.1Lex
Name: KISS1 receptor; targeted mutation 1.1, Lexicon Genetics
MGI ID: MGI:5316416
Gene: Kiss1r  Location: Chr10:79916971-79922273 bp, + strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:181650
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into exon 1. An additional loxP site and a lacZ with a nuclear localization sequence was inserted downstream of exon 5. Cre-mediated recombination removed the coding sequence. RT-PCR confirmed the absence of transcript expression in the hypothalamus. (J:181650)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 23 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kiss1r Mutation:  13 strains or lines available
References
Original:  J:181650 Garcia-Galiano D, et al., Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology. 2012 Jan;153(1):316-28
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory