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Targeted Allele Detail
Symbol: Pdilttm1Osb
Name: protein disulfide isomerase-like, testis expressed; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI ID: MGI:5316367
Gene: Pdilt  Location: Chr7:119486587-119523489 bp, - strand  Genetic Position: Chr7, 63.9 cM, cytoband F3
Germline Transmission:  Earliest citation of germline transmission: J:182133
Parent Cell Line:  EGR-05 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced by a neomycin resistance cassette in reverse orientation. Absence of mRNA in testes was confirmed by RT-PCR an absence of protein was established by immunoblot analysis. (J:182133)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pdilt Mutation:  16 strains or lines available
Original:  J:182133 Tokuhiro K, et al., Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3850-5
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory