Ihh^tm1.1Bhum
Targeted Allele Detail

Summary

• Symbol: Ihh^tm1.1Bhum
• Name: Indian hedgehog; targeted mutation 1.1, Brian D Humphreys
• MGI ID: MGI:5316284
• Synonyms: Ihh-nLacZ
• Gene: Ihh Location: Chr1:74984474-74990831 bp, - strand Genetic Position: Chr1, 38.55 cM
• Alliance: Ihh^tm1.1Bhum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182155
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A nuclear localization sequence, lacZ, and polyadenylation sequence replaced most of the first exon. Cre-mediated recombination replaced the floxed neo cassette inserted downstream of the reporter construct. (J:182155)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ihh Mutation: 22 strains or lines available

References

• Original: J:182155 Fabian SL, et al., Hedgehog-Gli Pathway Activation during Kidney Fibrosis. Am J Pathol. 2012 Apr;180(4):1441-53
• All: 2 reference(s)