Il33^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Il33^tm1Aki
• Name: interleukin 33; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:5316127
• Gene: Il33 Location: Chr19:29902514-29938118 bp, + strand Genetic Position: Chr19, 24.56 cM, cytoband C2
• Alliance: Il33^tm1Aki page

Il33^tm1Aki/Il33^tm1Aki mice show reduced accumulation of eosinophils in the lungs after S. venezuelensis infection

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182160
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neo cassette replaced part of exon 2 and all of exon 3. Western blot confirmed the absence of protein expression in the lungs. (J:182160)

Generation of the Il33^tm1Aki allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il33 Mutation: 30 strains or lines available

References

• Original: J:182160 Yasuda K, et al., Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3451-6
• All: 8 reference(s)