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Elavl1tm1.1Bndr
Targeted Allele Detail
Nomenclature
Symbol: Elavl1tm1.1Bndr
Name: ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R); targeted mutation 1.1, Jeffrey R Bender
MGI ID: MGI:5316082
Synonyms: HuRfl
Gene: Elavl1  Location: Chr8:4285382-4325413 bp, - strand  Genetic Position: Chr8, 2.0 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182000
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin selection cassette was inserted in intron 2 and a third loxP site was place upstream of exon 2 in intron 1. The selection cassette was subsequently removed as a result of cre expression leaving exon 2 flanked by loxP sites. (J:182000)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Elavl1 Mutation:  18 strains or lines available
References
Original:  J:182000 Zhang J, et al., Macrophage beta(2) Integrin-Mediated, HuR-Dependent Stabilization of Angiogenic Factor-Encoding mRNAs in Inflammatory Angiogenesis. Am J Pathol. 2012 Apr;180(4):1751-60
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory