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Prdm8tm1Mci
Targeted Allele Detail
Summary
Symbol: Prdm8tm1Mci
Name: PR domain containing 8; targeted mutation 1, Roderick R McInnes
MGI ID: MGI:5315763
Synonyms: Prdm8EGFP
Gene: Prdm8  Location: Chr5:98315241-98335313 bp, + strand  Genetic Position: Chr5, 47.77 cM, cytoband E3
Alliance: Prdm8tm1Mci page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:182304
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe second and third exon was replaced with an IRES-EGFP. Western blot analysis confirmed the absence of protein expression in the cortex. (J:182304)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prdm8 Mutation:  19 strains or lines available
References
Original:  J:182304 Ross SE, et al., Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Neuron. 2012 Jan 26;73(2):292-303
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory