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Slc12a6tm1.1Tjj
Targeted Allele Detail
Nomenclature
Symbol: Slc12a6tm1.1Tjj
Name: solute carrier family 12, member 6; targeted mutation 1.1, Thomas J Jentsch
MGI ID: MGI:5315722
Synonyms: Kcc3loxP
Gene: Slc12a6  Location: Chr2:112265825-112363163 bp, + strand  Genetic Position: Chr2, 56.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:181930
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted into intron 4. An additional loxP site was inserted into intron 6. Cre-mediated recombination removed the neo cassette and left exons 5 and 6 floxed. (J:181930)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc12a6 Mutation:  82 strains or lines available
References
Original:  J:181930 Seja P, et al., Raising cytosolic Cl(-) in cerebellar granule cells affects their excitability and vestibulo-ocular learning. EMBO J. 2012 Mar 7;31(5):1217-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory