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Targeted Allele Detail
Symbol: Ror2tm1.2Meg
Name: receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1.2, Michael E Greenberg
MGI ID: MGI:5315486
Synonyms: Ror2-, Ror2d
Gene: Ror2  Location: Chr13:53109317-53286124 bp, - strand  Genetic Position: Chr13, 27.68 cM, cytoband B3
Morphogenesis defects in Ror2tm1.2Meg/Ror2tm1.2Meg mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:182150
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Recombinase-mediated recombination removed the neo cassette and exons 3 and 4. Western blot analysis confirms the absence of protein expression in homozygous embryos. (J:182150)
Generation of Ror2tm1.1Meg and Ror2tm1.2Meg alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ror2 Mutation:  104 strains or lines available
Original:  J:182150 Ho HY, et al., Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4044-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory