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Chemically induced Allele Detail
Symbol: Tmc1stitch
Name: transmembrane channel-like gene family 1; stitch
MGI ID: MGI:5314996
Synonyms: Tmc1W554L
Gene: Tmc1  Location: Chr19:20783458-20954202 bp, - strand  Genetic Position: Chr19, 13.98 cM, cytoband B
Strain of Origin:  C57BL/6
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsENU induced a G to T mutation at position 1661 resulting in a tryptophan to leucine substitution at amino acid 554 in exon 15 and is predicted to alter protein folding. Protein expression is reduced in the type III fibrocytes basal to mid cochlear region but increased in the apical region in homozygous mice. (J:181985)
Inheritance:    Recessive
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tmc1 Mutation:  10 strains or lines available
Original:  J:181985 Manji SS, et al., Identification of three novel hearing loss mouse strains with mutations in the tmc1 gene. Am J Pathol. 2012 Apr;180(4):1560-9
All:  1 reference(s)

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MGI 5.21
The Jackson Laboratory