About   Help   FAQ
Targeted Allele Detail
Symbol: Srctm1Mul
Name: Rous sarcoma oncogene; targeted mutation 1, William J Muller
MGI ID: MGI:5314758
Synonyms: c-SrcL
Gene: Src  Location: Chr2:157423906-157471838 bp, + strand  Genetic Position: Chr2, 78.35 cM
Analysis of tumorigenesis

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:181822
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 4. An FRT-flanked neo, IRES, and GFP cassette with a 3' loxP site downstream of exon 6. Flp-mediated recombination removed the neo, IRES and GFP cassette. (J:181822)
(A) Generation of the conditional Srctm1Mul allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Src Mutation:  121 strains or lines available
Original:  J:181822 Marcotte R, et al., Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2808-13
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.15
The Jackson Laboratory