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b2b251Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b251Clo
Name: Mutant line 251; Bench to Bassinet Program (B2B/CVDC), mutation 251 Cecilia Lo
MGI ID: MGI:5313696
Gene: b2b251Clo  Location: unknown  
Malalignment of the great arteries suggest double outlet right ventricle (DORV) in mutant 251-007-1 (E15.5), which was subsequently confirmed by EFIC imaging.

Show the 15 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
    This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any b2b251Clo Mutation:  1 strain or line available
Notes
Summative Diagnosis:
Cardiovascular defect: Double outlet right ventricle (DORV), overriding aorta, perimembranous and muscular ventricular septal defects (VSD), and one mutant with hypoplastic transverse arch.
Non-cardiovascular phenotype: Cystic lungs.

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
1220 Tubular hypoplasia of aorta + coarctation
1310 Ventricular septal defect, membranous
1320 Ventricular septal defect, muscular
1340 Ventricular septal defect, ECD type
3810 Heart disease
4200 Respiratory anomaly

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory