Odf2^tm1.2Sats
Targeted Allele Detail

Summary

• Symbol: Odf2^tm1.2Sats
• Name: outer dense fiber of sperm tails 2; targeted mutation 1.2, Sachiko Tsukita
• MGI ID: MGI:5313543
• Synonyms: Odf2^deltaEx6,7, Odf2^flox-del
• Gene: Odf2 Location: Chr2:29779233-29821758 bp, + strand Genetic Position: Chr2, 20.79 cM, cytoband B
• Alliance: Odf2^tm1.2Sats page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181294
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed inverted MC1-neo cassette was inserted upstream of exon 6 and a loxP site was inserted downstream of exon 7 via homologous recombination. Cre mediated recombination removed the neo cassette and exons 6 and 7. Western blot analysis confirmed the absence of full length protein expression from this allele; however expression of a C terminal fragment was detected. (J:181294)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Odf2 Mutation: 35 strains or lines available

References

• Original: J:181294 Kunimoto K, et al., Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet. Cell. 2012 Jan 20;148(1-2):189-200
• All: 2 reference(s)