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Dpysl2tm1.1Gosh
Targeted Allele Detail
Summary
Symbol: Dpysl2tm1.1Gosh
Name: dihydropyrimidinase-like 2; targeted mutation 1.1, Yoshio Goshima
MGI ID: MGI:5312892
Synonyms: crmp2ki
Gene: Dpysl2  Location: Chr14:67040313-67106137 bp, - strand  Genetic Position: Chr14, 34.6 cM
Alliance: Dpysl2tm1.1Gosh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180581
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Single point mutation
 
Mutation detailsA floxed neo cassette was inserted upstream of exon 13 and a T to G mutation was introduced in exon 13 resulting in a Ser to Ala substitution at position 522 (S522A). Cre mediated recombination removed the neo cassette. In brain lysates from homozygous mice phosphorylation of Ser522 and Thr509 is completely suppressed. (J:180581)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dpysl2 Mutation:  34 strains or lines available
References
Original:  J:180581 Yamashita N, et al., Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Field Organization. J Neurosci. 2012 Jan 25;32(4):1360-1365
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory