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Il5tm1Ktk
Targeted Allele Detail
Nomenclature
Symbol: Il5tm1Ktk
Name: interleukin 5; targeted mutation 1, Kiyoshi Takatsu
MGI ID: MGI:5312092
Synonyms: Il5tm1.1Ktk, IL5V, IL5Venus
Gene: Il5  Location: Chr11:53720794-53725103 bp, + strand  Genetic Position: Chr11, 31.99 cM, cytoband A5/B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180790
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA Venus reporter and floxed neo cassette was inserted at the translation initiation site. Cre-mediated recombination removed the neo cassette. Flow cytometry confirmed the absence of protein expression in cultured Th2+ cells stimulated with PMA and ionomycin or anti-CD3 antibodies. (J:180790)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il5 Mutation:  24 strains or lines available
References
Original:  J:180790 Ikutani M, et al., Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity. J Immunol. 2012 Jan 15;188(2):703-13
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory