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Plectm7.1Gwi
Targeted Allele Detail
Nomenclature
Symbol: Plectm7.1Gwi
Name: plectin; targeted mutation 7.1, Gerhard Wiche
MGI ID: MGI:5311563
Synonyms: PlecOgna
Gene: Plec  Location: Chr15:76170975-76232574 bp, - strand  Genetic Position: Chr15, 35.48 cM
Skin abnormalities in heterozygous and homozygous Plectm7.1Gwi mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179812
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
 
Mutation details
Generation of the knock-in Plectm7.1Gwi allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plec Mutation:  14 strains or lines available
References
Original:  J:179812 Walko G, et al., Targeted proteolysis of plectin isoform 1a accounts for hemidesmosome dysfunction in mice mimicking the dominant skin blistering disease EBS-Ogna. PLoS Genet. 2011 Dec;7(12):e1002396
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory