About   Help   FAQ
Megf8b2b288Clo
Chemically induced Allele Detail
Nomenclature
Symbol: Megf8b2b288Clo
Name: multiple EGF-like-domains 8; Bench to Bassinet Program (B2B/CVDC), mutation 288 Cecilia Lo
MGI ID: MGI:5311364
Synonyms: M8, Megf8c.A3641T
Gene: Megf8  Location: Chr7:25317164-25365917 bp, + strand  Genetic Position: Chr7, 13.75 cM
Dextrocardia

Show the 10 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation details
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Megf8 Mutation:  4 strains or lines available
Notes
Summative Diagnosis:
Cardiovascular defects: Hetertoaxy with complex congenital heart disease such as transposition of the great arteries (TGA;{SDD}) and dextrocardia with double outlet right ventricle (DORV;{ILL}).
Non-cardiac phenotype: Cleft palate

Phenotypic Similarity to Human Syndrome: Heterotaxy, Carpenter Syndrome

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0190 Heterotaxy syndrome
0602 DORV, ventricular defect committed to aorta
0700 D-loop transposition of the great arteries
1120 Complete common atrioventricular canal
3804 Congenital heart disease
3950 {S,D,D}
3973 {I,L,L}
4846 Carpenter syndrome

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program. MGI Direct Data Submission (B2B/CvDC). 2011-13;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory