Mecp2^tm2.1Joez
Targeted Allele Detail

Summary

• Symbol: Mecp2^tm2.1Joez
• Name: methyl CpG binding protein 2; targeted mutation 2.1, Zhaolan Zhou
• MGI ID: MGI:5310728
• Synonyms: Mecp2^loxP
• Gene: Mecp2 Location: ChrX:73070198-73129296 bp, - strand Genetic Position: ChrX, 37.63 cM
• Alliance: Mecp2^tm2.1Joez page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181311
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: A targeting construct was designed to insert a loxP-flanked neomycin (neo) resistance cassette upstream of exon 4. Cre-mediated recombination removed the neo cassette. (J:181311)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mecp2 Mutation: 38 strains or lines available

References

• Original: J:181311 Goffin D, et al., Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses. Nat Neurosci. 2012 Feb;15(2):274-83
• All: 1 reference(s)