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Targeted Allele Detail
Symbol: Rhbdf2tm1.1Mfm
Name: rhomboid 5 homolog 2; targeted mutation 1.1, Matthew Freeman
MGI ID: MGI:5309177
Gene: Rhbdf2  Location: Chr11:116598165-116627019 bp, - strand  Genetic Position: Chr11, 81.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:179654
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 4 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 9 via homologous recombination. Cre mediated recombination removed exons 4 - 9 and the neo cassette. (J:179654)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rhbdf2 Mutation:  63 strains or lines available
Original:  J:179654 Adrain C, et al., Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE. Science. 2012 Jan 13;335(6065):225-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory