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Targeted Allele Detail
Symbol: Trap1atm1.1Jvde
Name: tumor rejection antigen P1A; targeted mutation 1.1, Benoit Van den Eynde
MGI ID: MGI:5309174
Synonyms: P1A-
Gene: Trap1a  Location: ChrX:139333683-139338169 bp, + strand  Genetic Position: ChrX, 61.35 cM
Germline Transmission:  Earliest citation of germline transmission: J:180807
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsInsertion of loxP sites, one into the Acc65I site located 15 bp upstream of the ATG in the first exon, and the other into the PstI site located in the first intron. Cre-mediated recombination removed exon 1. RT-PCR confirmed the absent of transcripts containing exon 1 in the testes and thymus. (J:180807)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trap1a Mutation:  7 strains or lines available
Original:  J:180807 Huijbers IJ, et al., Minimal tolerance to a tumor antigen encoded by a cancer-germline gene. J Immunol. 2012 Jan 1;188(1):111-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
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