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Cd8atm2.1(Cd4)Asin
Targeted Allele Detail
Nomenclature
Symbol: Cd8atm2.1(Cd4)Asin
Name: CD8 antigen, alpha chain; targeted mutation 2.1, Alfred Singer
MGI ID: MGI:5309010
Synonyms: 4in8, Cd8aCD4
Gene: Cd8a  Location: Chr6:71373427-71379171 bp, + strand  Genetic Position: Chr6, 32.14 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180236
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-4 were replaced with a Cd4 cDNA and a floxed neomycin selection cassette. The selection cassette was subsequently removed by cre excision. (J:180236)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd8a Mutation:  13 strains or lines available
References
Original:  J:180236 Adoro S, et al., Coreceptor gene imprinting governs thymocyte lineage fate. EMBO J. 2011;31(2):366-77
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory