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Lbrlym3
Chemically induced Allele Detail
Nomenclature
Symbol: Lbrlym3
Name: lamin B receptor; lymphocyte affected 3
MGI ID: MGI:5308091
Gene: Lbr  Location: Chr1:181815335-181843046 bp, - strand  Genetic Position: Chr1, 84.89 cM
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU mutagenesis induced a C to A nucleotide substitution in exon 10 that results in the amino acid substitution of alanine for glutamic acid at position 418 (E418A). (J:180355)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lbr Mutation:  17 strains or lines available
Notes
Originally isolated from Mpltm1Wsa mice treated with ENU.

References
Original:  J:180355 Verhagen AM, et al., Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. J Immunol. 2012 Jan 1;188(1):122-34
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory