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Cd207tm2.1(cre)Bjec
Targeted Allele Detail
Nomenclature
Symbol: Cd207tm2.1(cre)Bjec
Name: CD207 antigen; targeted mutation 2.1, Bjorn Clausen
MGI ID: MGI:5308064
Synonyms: Langerin-Cre
Gene: Cd207  Location: Chr6:83648197-83654839 bp, - strand  Genetic Position: Chr6, 35.94 cM, cytoband D1-D2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179630
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA cDNA encoding cre recombinase with a bovine polyadenylation sequence and a nuclear localization signal (NLS) and followed by an Frt-flanked neo cassette was inserted into exon 2 of Cd207 (langerin) by homologous recombination. After verifying germline transmission, the neo resistance cassette was deleted from the allele by breeding founders to FLPe-expressing mice. (J:179630)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cd207     Summary of all recombinase alleles driven by Cd207.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd207 Mutation:  20 strains or lines available
References
Original:  J:179630 Zahner SP, et al., Conditional deletion of TGF-betaR1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity. J Immunol. 2011 Nov 15;187(10):5069-76
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory