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Tg(ED-L2-IL1RN/IL1B)#Tcw
Transgene Detail
Nomenclature
Symbol: Tg(ED-L2-IL1RN/IL1B)#Tcw
Name: transgene insertion, Timothy C Wang
MGI ID: MGI:5308012
Synonyms: L2-IL-1Beta
Transgene: Tg(ED-L2-IL1RN/IL1B)#Tcw  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x SJL
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(ED-L2-IL1RN/IL1B)#Tcw expresses 2 genes
 
Mutation detailsThe Epstein-Barr virus ED-L2 promoter drives expression of a modified human IL1B cDNA. The modified human IL1B cDNA consists of the IL1RN signal sequence and a cDNA encoding for the 17 kDa mature human IL1B. Two lines were generated one with high expression and one with low expression. (J:180282)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:180282 Quante M, et al., Bile Acid and inflammation activate gastric cardia stem cells in a mouse model of barrett-like metaplasia. Cancer Cell. 2012 Jan 17;21(1):36-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory