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Tg(CTSG-NUMA1/RARA)#Skr
Transgene Detail
Nomenclature
Symbol: Tg(CTSG-NUMA1/RARA)#Skr
Name: transgene insertion, Suzanne Kamel-Reid
MGI ID: MGI:5307058
Synonyms: hCG-NuMA-RARalpha TM
Transgene: Tg(CTSG-NUMA1/RARA)#Skr  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CTSG-NUMA1/RARA)#Skr expresses 2 genes
 
Mutation detailsThis transgene consists of a fusion protein containing the N-terminal globular head domain and long central coiled-coil motif of NUMA1, including the oligomerization domain, and the C-terminus, domains C-F, of RARA, including the ATRA-binding site, RA-dependent DNA-binding site, and retinoid X receptor alpha and nuclear corepressor/coactivator interfaces, under the control of the human cathepsin G promoter. This fusion protein results from a translocation t(11:17)(q13;q21) associated with human cases of acute promyelocytic leukemia. The CTSG promoter drives expression in immature cells of the neutrophil lineage. RT-PCR indicates transgene expression in multiple organs at 4.5 months of age. Two lines were made but no line numbers were specified. (J:88103)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:88103 Sukhai MA, et al., Myeloid leukemia with promyelocytic features in transgenic mice expressing hCG-NuMA-RARalpha. Oncogene. 2004 Jan 22;23(3):665-78
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory