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Targeted Allele Detail
Symbol: Irf6tm1.1Bcsl
Name: interferon regulatory factor 6; targeted mutation 1.1, Brian C Schuttes
MGI ID: MGI:5306935
Synonyms: Irf6del, Irf6nl
Gene: Irf6  Location: Chr1:193153111-193172023 bp, + strand  Genetic Position: Chr1, 97.6 cM
Germline Transmission:  Earliest citation of germline transmission: J:180634
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsLoxP sites were inserted in introns 2 and 4. Subsequent cre excision deleted exons 3 and 4 which contain critical sequences of the DNA binding domain and causes a frameshift mutation. (J:180634, J:242906)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irf6 Mutation:  5 strains or lines available
Original:  J:180634 Biggs LC, et al., Interferon regulatory factor 6 is necessary, but not sufficient, for keratinocyte differentiation. J Invest Dermatol. 2012 Jan;132(1):50-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory