Cd40lg^tm1Parl
Targeted Allele Detail

Summary

• Symbol: Cd40lg^tm1Parl
• Name: CD40 ligand; targeted mutation 1, Roberto Parrilla
• MGI ID: MGI:5306631
• Synonyms: CD40L^floxed
• Gene: Cd40lg Location: ChrX:56257503-56269402 bp, + strand Genetic Position: ChrX, 31.21 cM
• Alliance: Cd40lg^tm1Parl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164716
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 and 4 were flanked ny loxP sites. Cre-mediated recombination removed the neomycin resistance cassette inserted downstream of exon 4. (J:164716)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd40lg Mutation: 14 strains or lines available

References

• Original: J:164716 Nowakowski A, et al., Megakaryocyte gene targeting mediated by restricted expression of recombinase Cre. Thromb Haemost. 2010 Oct 12;105(1)
• All: 2 reference(s)