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Agttm1.1Itl
Targeted Allele Detail
Nomenclature
Symbol: Agttm1.1Itl
Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8); targeted mutation 1.1, inGenious Targeting Laboratory
MGI ID: MGI:5305952
Synonyms: Agtfl
Gene: Agt  Location: Chr8:124556587-124569706 bp, - strand  Genetic Position: Chr8, 72.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178836
Parent Cell Line:  iTL IC1 (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and an FRT and loxP flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination deleted the neo cassette leaving exon 2 floxed. (J:178836)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Agt Mutation:  8 strains or lines available
References
Original:  J:178836 Yiannikouris F, et al., Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice. Am J Physiol Regul Integr Comp Physiol. 2012 Jan 15;302(2):R244-51
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory