Tdrd6^tm1Chum
Targeted Allele Detail

Summary

• Symbol: Tdrd6^tm1Chum
• Name: tudor domain containing 6; targeted mutation 1, Shinichiro Chuma
• MGI ID: MGI:5305938
• Gene: Tdrd6 Location: Chr17:43926226-43941190 bp, - strand Genetic Position: Chr17, 19.75 cM
• Alliance: Tdrd6^tm1Chum page

Spermiogenesis defect in Tdrd6^tm1Chum/Tdrd6^tm1Chum males

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173550
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A 2.6 kb segment in the first exon (NM_198418, 99-26098) was replaced with a neomycin resistence gene. (J:173550)

Generation of the Tdrd6^tm1Chum allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tdrd6 Mutation: 80 strains or lines available

References

• Original: J:173550 Tanaka T, et al., Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10579-84
• All: 1 reference(s)