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Fgf23tm1.1Kew
Targeted Allele Detail
Nomenclature
Symbol: Fgf23tm1.1Kew
Name: fibroblast growth factor 23; targeted mutation 1.1, Kenneth E White
MGI ID: MGI:5305729
Synonyms: ADHR, Fgf23R176Q
Gene: Fgf23  Location: Chr6:127072902-127081408 bp, + strand  Genetic Position: Chr6, 61.92 cM
Fgf23tm1.1Kew/Fgf23tm1.1Kew mice fed a low-iron diet exhibit osteomalacia

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180061
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Single point mutation
 
Mutation details
Gene targeting to generate the Fgf23tm1.1Kew allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf23 Mutation:  3 strains or lines available
References
Original:  J:180061 Farrow EG, et al., Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1146-55
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory