About   Help   FAQ
Targeted Allele Detail
Symbol: Fgf23tm1.1Kew
Name: fibroblast growth factor 23; targeted mutation 1.1, Kenneth E White
MGI ID: MGI:5305729
Synonyms: ADHR, Fgf23R176Q
Gene: Fgf23  Location: Chr6:127072902-127081408 bp, + strand  Genetic Position: Chr6, 61.92 cM
Fgf23tm1.1Kew/Fgf23tm1.1Kew mice fed a low-iron diet exhibit osteomalacia

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:180061
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Humanized sequence)
Mutations:    Insertion, Single point mutation
Mutation detailsExon 3 was replaced with a floxed neo cassette and a modified exon 3 in which a silent mutation inserted a SacI site and a nucleotide substitutions (CGC to CAG) results in the amino acid substitution of glutamine for arginine at position 176 (R176Q), mimicking a mutation found in some autosomal dominant hypophosphatemic rickets (ADHR) patients. Cre-mediated recombination removed the neo cassette. (J:180061)
Gene targeting to generate the Fgf23tm1.1Kew allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf23 Mutation:  6 strains or lines available
Original:  J:180061 Farrow EG, et al., Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice. Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1146-55
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory