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Targeted Allele Detail
Symbol: Apctm1.1Alew
Name: APC, WNT signaling pathway regulator; targeted mutation 1.1, Anabelle Lewis
MGI ID: MGI:5305725
Synonyms: APC1322T
Gene: Apc  Location: Chr18:34220924-34322552 bp, + strand  Genetic Position: Chr18, 18.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:180275
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette replaced the sequence corresponding to amino acids 1323 to 2845 and resulted in the deletion of all but one 20AAR domain with a truncation of the produced protein at 1322 (1322T). Cre-mediated recombination removed the floxed neo cassette inserted downstream of the modified exon 15. (J:180275)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:  59 strains or lines available
Original:  J:180275 Pollard P, et al., The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression. Gastroenterology. 2009 Jun;136(7):2204-2213.e1-13
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory