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Pbx1tm1Koss
Targeted Allele Detail
Nomenclature
Symbol: Pbx1tm1Koss
Name: pre B cell leukemia homeobox 1; targeted mutation 1, Matthew J Koss
MGI ID: MGI:5305253
Synonyms: Pbx1f, Pbx1flox
Gene: Pbx1  Location: Chr1:168119364-168432264 bp, - strand  Genetic Position: Chr1, 75.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178316
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 3. (J:184521)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pbx1 Mutation:  18 strains or lines available
References
Original:  J:178316 Ferretti E, et al., A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis. Dev Cell. 2011 Oct 18;21(4):627-41
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory